Inhaled Iloprost as a First-Line Therapy for Persistent Pulmonary Hypertension of the Newborn

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A case of persistent pulmonary hypertension of the newborn: Treatment with inhaled iloprost

We report a case of a full-term neonate with persistent pulmonary hypertension who developed asphyxia after birth and was treated with iloprost. The neonate had persistent hypoxia and did not respond to supportive treatment. Because inhaled nitric oxide (iNO) was not available in our hospital, inhaled iloprost was administered via an endotracheal tube. This resulted in an immediate elevation of...

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Inhaled iloprost for therapy in pulmonary arterial hypertension.

Iloprost (Ventavis, Bayer Schering Pharma, Germany) is a synthetic prostacyclin that is used in its inhalative form for the therapy of pulmonary arterial hypertension. Long-term therapy can increase exercise capacity and quality of life. The use of modern nebulizers especially designed for the administration of iloprost guarantees the pulmonary deposition of the required doses and systematicall...

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Inhaled iloprost for sarcoidosis associated pulmonary hypertension.

RATIONALE Patients with sarcoidosis associated pulmonary hypertension (SAPH) have responded to systemic prostacyclin therapy. OBJECTIVES To determine the rate of response to inhaled prostacyclin, iloprost, in SAPH. METHODS Sarcoidosis patients with pulmonary hypertension and no evidence for left ventricular dysfunction were enrolled in an open label, prospective study. Patients underwent ri...

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Inhaled iloprost for severe pulmonary hypertension.

BACKGROUND Uncontrolled studies suggested that aerosolized iloprost, a stable analogue of prostacyclin, causes selective pulmonary vasodilatation and improves hemodynamics and exercise capacity in patients with pulmonary hypertension. METHODS We compared repeated daily inhalations of 2.5 or 5.0 microg of iloprost (six or nine times per day; median inhaled dose, 30 microg per day) with inhalat...

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Inhaled nitric oxide in persistent pulmonary hypertension of the newborn.

Nitric oxide (NO) has vasodilatory effects on the pulmonary vasculature in adults and animals. We examined the effects on systemic oxygenation and blood pressure of inhaling up to 80 parts per million by volume of NO at FiO2 0.9 for up to 30 minutes by 6 infants with persistent pulmonary hypertension of the newborn (PPHN). In all infants this treatment rapidly and significantly increased preduc...

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ژورنال

عنوان ژورنال: Neonatal Medicine

سال: 2019

ISSN: 2287-9412,2287-9803

DOI: 10.5385/nm.2019.26.4.191